Key Publications
Immuno-Oncology
Wang C. and Steinmetz N.F. (2020) A Combination of Cowpea mosaic virus and Immune Checkpoint Therapy Synergistically Improves Therapeutic Efficacy in Three Tumor Models. Advanced Functional Materials, accepted. PMID: pending, PMCID: pending.
Cai H.*, Wang C.*, Shukla S.*, Steinmetz N.F. (2019) Cowpea Mosaic Virus Immunotherapy Combined with Cyclophosphamide Reduces Breast Cancer Tumor Burden and Inhibits Lung Metastasis. Adv. Sci. 2019, 1802281. PMID: 31453050, PMCID: PMC6702650.
Wang C.*, Fiering S., Steinmetz N.F. (2019) Cowpea Mosaic Virus Promotes Anti-Tumor Activity and Immune Memory in a Mouse Ovarian Tumor Model. Advanced Therapeutics. 1900003. PMID: pending, PMCID: pending (NIHMS 1066974).
Lizotte, H, Wen, A.M., Sheen, M.R., Fields, J., Rojanasopondist, P., Steinmetz, N.F., Fiering, S.(2016) In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer. Nature Nanotechnology, 11, 295-303. #co-corresponding authors.
Immuno-Oncology - Veterinary
Hoopes P.J., Wagner R.J.,Duval K., Kang K., Gladstone D.J., Moodie K.L., Crary-Burney M., Ariaspulido H., Veliz F.A.*, Steinmetz N.F.#, Fiering S.# (2018) Treatment of canine oral melanoma with nanotechnology-based immunotherapy and radiation. Mol Pharm., 15, 3717-3722. PMID: 29613803, PMCID: PMC6296751. #co-corresponding authors.
Vaccine
Shin M.D.#, Shukla S.#, Chung Y. H., Beiss V., Chan S. K., Ortega-Rivera O. A., Wirth D. M., Chen A., Sack M., Pokorski J. K., Steinmetz N.F. (2020) COVID-19 vaccine development and a potential nanomaterial path forward. Nature Nanotechnology, 15, 646-655. https://doi.org/10.1038/s41565-020-0737-y.
Lee P.W., Shukla S., Wallat J.D., Danda C., Steinmetz N.F., Maia J., Pokorski J.K. (2017) Biodegradable Viral Nanoparticle/Polymer Implants Prepared via Melt-Processing. ACS Nano, 11,8777-8789.
Grants
Mosaic’s IO and VAX technology has been developed over the past ten years by the Principal Investigators and Co-Founders of Mosaic: Drs. Steinmetz, Pokorski, and Fiering. The technology development has been supported through numerous federal research grants, including NIH, NSF, and CDMRP as well as private foundations, such as the American Cancer Society, Susan G Komen, and American Heart Association totaling $21 Million.