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Veterinary 

Immuno-Oncology

Ongoing individual treatment regimens consistently demonstrate antitumor activity utilizing CPMV alone or in combination with standard therapies against naturally occurring cancers in canine companion animals. Data to date demonstrate similar effects as those observed in preclinical tumor models evaluating CPMV. We believe these ongoing canine oncology studies provide valuable proof of concept data regarding the consistency of MIE-101's immune stimulation and antitumor effects across species. Additionally, insights into dosing amount and frequency, combined with immune modulating details available from biopsies of treated animals could help to inform and support the design of human clinical trials currently in planning stages. We are also investigating and evaluating regulatory requirements regarding the approval of canine oncology therapeutics which may provide a separate and expedited path toward the commercialization of our technology.

​​Activity in multiple tumor types​

• Melanoma​

• Mammary​

• Sarcoma​

• Amelioblastoma​

• Mast cell​

• Others​

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Treatment regimens​

• Intratumoral single agent CPMV​

• Combination with radiation

• Combination with hyperthermia​

• Combination with chemotherapies​

Observations​​

• Single agent anti-tumor activity​​

• Combination treatment activity​​

• Increased anti-tumor immune cell infiltrate in tumors​​

• Systemic anti-tumor responses (abscopal effect observed)